city, seat (1832) of Franklin county, northwestern Florida, U.S. It lies on Apalachicola Bay (bridged) at the mouth of the Apalachicola River, on the Intracoastal Waterway, about 80 miles (130 km) southwest of Tallahassee.

Founded about 1820 as West Point (renamed Apalachicola in 1831), the town was an important cotton-shipping port from the early 1830s until a blockade during the American Civil War ended this activity. After the war, the lumber industry (based on cypress) became important; fishing also gained in prominence, and sponges were a major commodity during the late 1800s. In the 1840s John Gorrie (Gorrie, John), a doctor in Apalachicola, invented a refrigeration apparatus to cool the rooms of yellow-fever patients (commemorated by the John Gorrie State Museum). The city's name is derived from either a Hitchiti Indian word meaning “people on the other side” or a Choctaw word meaning “allies.”

An important seafood-producing centre, Apalachicola is Florida's largest producer of oysters. Tourism is another mainstay of the economy. Among the city's attractions is the Ionic-columned Trinity Episcopal Church (1838), a notable landmark that was built with wood shipped from New York. The Apalachicola Maritime Museum preserves the restored 1877 schooner Governor Stone. Nearby to the east are St. George Island, including St. George Island State Park, and to the north, Apalachicola National Forest. At the western end of the bay, St. Vincent National Wildlife Refuge, on St. Vincent Island, provides habitat for endangered species such as the red wolf. The Apalachicola National Estuarine Research Reserve, established in 1979, covers more than 385 square miles (1,000 square km) and encompasses both land and water areas of the bay and river. Inc. town, 1829; city, 1838. Pop. (1990) 2,602; (2000) 2,334.