Spanish soldier and colonial administrator who led the first Spanish expedition to found permanent colonies on the American mainland.

A soldier in his youth, Arias Dávila served with distinction in wars against the Moors in Granada in the 1490s and in North Africa in 1508–11. It is believed that he owed his appointment as captain general of the Spanish lands in the New World, which he received in 1513, to the bishop of Burgos. Arias Dávila sailed for the New World in 1514 with 19 ships and about 1,500 men.

Arias Dávila's accomplishments include establishing colonies in what are now Panama (1514) and Nicaragua (1522), serving as governor of Panama (1514–26) and Nicaragua (1527–31), and founding Panama City (1519). He also sent out expeditions of conquest, such as that led by Hernán Ponce and Bartolomé Hurtado to what are now Costa Rica and Nicaragua in 1516 and that led by Francisco Pizarro and Diego de Almagro, which left in 1524 to conquer the Inca empire in what is now Peru. Arias Dávila, however, has been described both as being too old and as lacking the intellectual and moral capacity needed by a captain general. He seems to have deliberately promoted discord among the captains placed under his command, and he was held responsible for the trial and execution of the explorer Vasco Núñez de Balboa in 1519.