Homer, in the Iliad, mentions him only as a skillful physician and the father of two Greek doctors at Troy, Machaon and Podalirius; in later times, however, he was honoured as a hero and eventually worshiped as a god. The cult began in Thessaly but spread to many parts of Greece. Because it was supposed that Asclepius effected cures of the sick in dreams, the practice of sleeping in his temples in Epidaurus in South Greece became common. In 293 BC his cult spread to Rome, where he was worshiped as Aesculapius.

Asclepius was frequently represented standing, dressed in a long cloak, with bare breast; his usual attribute was a staff with a serpent coiled around it. This staff is the only true symbol of medicine. A similar but unrelated emblem, the caduceus, with its winged staff and intertwined serpents, is frequently used as a medical emblem but is without medical relevance since it represents the magic wand of Hermes, or Mercury, the messenger of the gods and the patron of trade.