Red Sea port, southeastern Eritrea. It lies at the entrance of Asseb Bay and is Eritrea's second most important port (after Massawa).

Formerly a terminus of caravan routes across the arid Denakil Plain, the Asseb coastal strip was acquired by Italian shipping interests in 1869 and in 1882 became the first Italian colonial possession in Africa. Under Italian rule, the port became a free-trade zone for landlocked Ethiopia and was connected by road to Dese, in the Ethiopian highlands on the Addis Ababa–Asmara highway. After Eritrea's federation with Ethiopia in 1952 (and incorporation in 1962), Asseb became an important port of entry for the southern and central parts of the country. It eventually handled 70 percent of Ethiopia's export-import trade, acquired a small naval garrison, and in 1967 became the site of Ethiopia's first petroleum refinery. After the secession of Eritrea in 1993, Asseb remained an open port for Ethiopia. Besides the refinery, the town has a saltworks and a water distillation plant. Pop. (1992 est.) 50,000.