Atmospheric pressure is expressed in several different systems of units: millimetres (or inches) of mercury, pounds per square inch (psi), dynes per square centimetre, millibars (millibar) (mb), standard atmospheres (standard atmosphere), or kilopascals. Standard sea-level pressure, by definition, equals 760 mm (29.92 inches) of mercury, 14.70 pounds per square inch, 1,013.25 × 10³ dynes per square centimetre, 1,013.25 millibars, one standard atmosphere, or 101.35 kilopascals. Variations about these values are quite small; for example, the highest and lowest sea-level pressures ever recorded are 32.01 inches (in the middle of Siberia) and 25.90 inches (in a typhoon in the South Pacific). The small variations in pressure that do exist largely determine the wind and storm patterns of the Earth.

Near the Earth's surface the pressure decreases with height at a rate of about 3.5 millibars for every 30 metres (100 feet). However, over cold air the decrease in pressure can be much steeper because its density is greater than warmer air. The pressure at 270,000 metres (10⁻⁶ mb) is comparable to that in the best man-made vacuum ever attained. At heights above 1,500 to 3,000 metres (5,000 to 10,000 feet), the pressure is low enough to produce mountain sickness and severe physiological problems unless careful acclimatization is undertaken.