U.S. astronomer who discovered the sixth and seventh moons of Jupiter in 1904 and 1905, respectively. In 1904 he published a calculation of the solar parallax (a measure of the Earth–Sun distance) based on observations of the minor planet Eros during one of its close approaches to the Earth.

Perrine worked at the Lick Observatory in California from 1893 to 1909 and then until his retirement in 1936 was director of the Argentine National Observatory in Córdoba. His work included counts of extragalactic nebulae and the discovery of 13 comets.