entertainer renowned as America's greatest voice-over artist who created more than 400 unique voices for popular radio, television, movie, and cartoon characters.

Blanc was interested in music at an early age and became proficient on bass, violin, and sousaphone. He began his professional life as a radio musician in the late 1920s, and in 1933 he and his wife cohosted a daily radio program from Portland, Oregon. As the low-budgeted show did not allow for the hiring of supporting actors on a daily basis, Blanc was compelled to provide a variety of voices himself and thus began honing the skills that brought him success. He did freelance work for Los Angeles-area radio stations throughout the 1930s and in 1937 joined Leon Schlesinger's animation unit at Warner Bros. (Warner Brothers) studios. Nicknamed “Termite Terrace” because of its spartan accommodations on the Warner lot, Schlesinger's unit produced the enormously popular and enduringly influentialLooney Tunes and Merrie Melodies cartoon shorts. Blanc's first assignment for the company was to give voice to a drunken bull in the 1937 short Picador Porky.

During more than 50 years in show business, Blanc provided voices for some 3,000 cartoons produced by various studios, but he is associated most with the work he did for Warner Bros. He created voices for an estimated 90 percent of Warner characters, including such cartoon stars as Bugs Bunny, Daffy Duck, Porky Pig, Tweety Pie, Sylvester, Foghorn Leghorn, and the Road Runner. Blanc's vocal dexterity also made him a success in radio, where he was a regular cast member for years on the Burns and Allen (Burns, George) and Abbott and Costello shows; he was also the host of his own show during the late 1940s. His best-known radio work was as a semiregular on The Jack Benny Show, for which he provided his usual array of voices, as well as the sputtering, wheezing noises of Benny's Maxwell automobile.

During the 1950s and '60s Blanc continued his work for Warners and provided voices for television cartoons, most notably that of Barney Rubble in The Flintstones (1960–66). With his son, he opened a school for voice-over artists in the 1970s. His last major assignment was to provide voices for his most familiar characters in the feature Who Framed Roger Rabbit? (1988). That same year his autobiography, That's Not All, Folks: My Life in the Golden Age of Cartoons and Radio, was published. Since his death, other actors have assumed the voices of the Looney Tunes characters, but none has been able to match Blanc's superb comic timing and sense of the ridiculous, not to mention the many nuances he brought to the characters.