Sancti Spíritus
Cuba
city, central Cuba. Founded in 1516 on the Tuinicú River, the settlement was moved to the banks of the Yayabo River in 1524. It is the oldest city of interior Cuba, and narrow, crooked streets, old churches, and plazas preserve its colonial atmosphere. The city serves as the commercial centre of a fertile agricultural region that produces sugarcane, tobacco, and dairy products. It lies on the central highway, about 30 mi (50 km) from its port, Trinidad. Pop. (2002) 98,283.