Italian Gothic-style church of the Dominicans in Florence. It was planned by two Dominican brothers, Sisto and Ristoro, and construction began c. 1278 and was completed in 1350, except for the facade, which was completed by Leon Battista Alberti (Alberti, Leon Battista) in proto-Renaissance style (1456–70).

Frescoes painted on the interior walls of the church, cloister, and chapterhouse are by such Italian masters of Gothic and early Renaissance painting as Andrea Orcagna (Orcagna, Andrea), Andrea da Firenze, Masaccio (The Trinity fresco), Domenico Ghirlandaio (Ghirlandaio, Domenico), Filippino Lippi (Lippi, Filippino), and Paolo Uccello (Uccello, Paolo). Santa Maria Novella also houses important early Renaissance works of sculpture by Filippo Brunelleschi (Brunelleschi, Filippo) and Benedetto da Maiano.