Lydia Huntley worked as a schoolteacher and published her first work, Moral Pieces in Prose and Verse, in 1815. After her marriage in 1819 to Charles Sigourney (d. 1854), a merchant, she devoted her life to writing. She wrote some 67 books and more than a thousand articles during her career; many were widely read in Europe as well as in the United States. Such editors as Louis Godey of the Lady's Book (later Godey's Lady's Book) and Edgar Allan Poe (Poe, Edgar Allan) of Graham's Lady's and Gentleman's Magazine vied for her contributions.

Sigourney's writing relied on sentimental conventions of moral and religious themes; death and piety were her most popular subjects. Her best-known prose work was Letters to Young Ladies (1833); her Illustrated Poems (1849) was published in a series that included the poems of Henry Wadsworth Longfellow. Her autobiography, Letters of Life, appeared in 1866.