At age 16 Cher moved to Los Angeles, where she met entertainer and songwriter Salvatore (“Sonny”) Bono, whom she married in 1964. The couple began singing together, and their first big pop hit came in 1965 with "I Got You Babe," which sold more than three million copies. The duo went on to score a number of hits, but by the late 1960s their popularity had begun to fade. A jump start came in 1971 with the television variety show The Sonny and Cher Comedy Hour, which ran until 1974. During this time Cher's solo singing career flourished. Cher and Sonny divorced in 1974, though they appeared as cohosts of another television show in 1976–77.

After Sonny left show business, Cher cultivated a successful nightclub act and revisited an earlier interest in acting. She appeared in the Broadway and film versions of Come Back to the Five and Dime, Jimmy Dean, Jimmy Dean (1982) and received an Academy Award nomination for her supporting role in Silkwood (1983). In 1988 she won an Academy Award for her starring role as an Italian American widow in the romantic comedy Moonstruck (1987). Her others films included Mask (1985), Suspect (1987), and Tea with Mussolini (1999). After two successful albums—Cher (1987) and Heart of Stone (1989)—Cher's music career waned, but she made a comeback with Believe (1998) and Living Proof (2002). In 2000 she won a Grammy Award for the dance single "Believe."