In 1444 Christus became a citizen of Bruges, where he worked until his death. He is believed to have been trained in Jan van Eyck's studio. His naturalistic mature style, characterized by jewellike execution, is a simplified adaptation of his supposed master's style. But some of his motifs and compositions were drawn from the emotional tradition of Early Netherlandish art.

Christus' historical significance lies primarily in his intense interest in the definition of space; his “Virgin with SS. Jerome and Francis” is the earliest Netherlandish painting with a single vanishing point. Among Christus' most important paintings are “Portrait of a Carthusian” (1446), “St. Eligius” (1449), the “Virgin with SS. Jerome and Francis” (probably 1457), and the “Virgin with Child, St. Barbara and a Carthusian Monk.”