brother-in-law of the English king Henry VIII and a prominent courtier during his reign.

His father, William Brandon, died fighting for Henry Tudor (later King Henry VII) in 1485. A large, athletic man, young Brandon was about the only member of Henry VIII's entourage capable of standing up to Henry VIII in a tournament. He proved his personal courage in the 1513 campaign against France (for which he received a viscountcy), but, when he was later given military commands (1523 and 1542–44), he displayed only incompetence.

In February 1514, Henry made Brandon Duke of Suffolk. Early the following year Suffolk was sent to Paris to promote a match between Henry's sister Mary and King Francis I of France; instead Suffolk married her himself, thereby incurring the danger of being accused of treason. Henry's wrath was apparently assuaged by his chief minister, Thomas Cardinal Wolsey, and the duke soon returned to royal favour. Nevertheless, in 1529 Suffolk helped overthrow Wolsey, and for several years thereafter he appeared to be among the dominant members of the king's council, though he was a man devoid of the qualities of leadership. He welcomed the demise of Anne Boleyn. Suffolk's granddaughter, Lady Jane Grey, was titular queen of England for nine days following the death of King Edward VI in 1553.