Suzuki played baseball from an early age. Upon finishing high school, he was drafted by the Orix Blue Wave of the Japanese Pacific League (see also Japanese baseball leagues). He saw limited action during his first two seasons because his manager disliked the young player's unorthodox batting style—a sort of pendulum motion created by kicking the front foot back and then striding forward with the swing. In 1994 a new manager gave Suzuki a starting spot on the team and let him swing the way he liked. He responded in amazing fashion, lifting his batting average to .400 during the season and finishing at .385—the second best batting mark in the history of Japanese baseball. He collected 210 hits, a record for one season. Through 2000 he won seven consecutive Pacific League batting titles, posted a career average of .353, and led his team to two pennants. He was not a power hitter, but his speed and bat control were unmatched. He was also considered among the top outfielders, with the strongest, most accurate throwing arm in the league. Suzuki threw right-handed but batted left-handed.

By 2000 Suzuki had established himself as the best baseball player in Japan and had begun his quest for stardom in the United States. He spent two weeks in the Seattle Mariners' 1999 spring training camp as part of a U.S.-Japan player exchange. A Japanese player in an American lineup was no longer quite the rarity it once had been; several Japanese pitchers, most notably Hideo Nomo (Nomo Hideo) and Hideki Irabu, had crossed the Pacific to play in the major leagues. Suzuki became the first nonpitcher to make the transition when he signed a three-year contract with the Mariners in November 2000. Because pitchers in the United States threw harder than their Japanese counterparts, some observers believed that Japanese hitters would struggle at the plate.

Suzuki made his major league debut with the Mariners on April 2, 2001. He answered his critics with a stellar season, capturing the American League (AL) Rookie of the Year award and a Gold Glove. His batting average in the 2001 regular season was .350, and it was .421 in the postseason games. In 2004 Suzuki broke George Sisler (Sisler, George)'s 84-year-old record for most hits in a single season, ending the year with 262 hits and a .372 batting average. He collected more than 200 hits—and was named to the AL All-Star team—in each of his first seven seasons with the Mariners.