A student of the famous still-life painter Blas del Prado, Sánchez was early influenced by the spirit of Catholic mysticism that dominated the intellectual life of Toledo at the time. Entering a monastery in Segovia in 1603 as a Carthusian lay brother, he was transferred to Granada in 1612 and remained there until his death.

Although he painted other subjects, it is for his still lifes that Sánchez is remembered. They are marked by a detailed realism and a sense of volume and depth. His concern with the relationships among objects and with achieving the illusion of reality through the use of light and shadow was a major influence on the work of Francisco de Zurbarán and other later Spanish painters.