Tissue affected by phosphoinositide second-messenger system

extracellular signal target tissue cellular response

acetylcholine pancreas

pancreas (islet cells)

smooth muscle amylase secretion

insulin release

contraction

vasopressin liver

kidney glycogenolysis

thrombin blood platelets platelet aggregation

antigens lymphoblasts

mast cells DNA synthesis

histamine secretion

growth factors fibroblasts DNA synthesis

spermatozoa eggs (sea urchin) fertilization

light photoreceptors (horseshoe crab) phototransduction

thyrotropin-releasing hormone pituitary anterior lobe prolactin secretion

Source: From Christopher K. Mathews, K.E. van Holde, and Kevin G. Ahern, Biochemistry, 3rd ed. (2000),

Table 23.5.