Spanish scholar and humanist, one of the most important figures of the abortive Spanish Reformation.

While studying at Wittenberg University, Enzinas became a friend and protégé of the Lutheran reformer Philipp Melanchthon (Melanchthon, Philipp). Enzinas' Spanish translation of the New Testament, which was published in Antwerp in 1543, was proscribed by the Spanish Inquisition, but he escaped to Wittenberg. He founded a Protestant colony in Constantinople (now Istanbul) and then taught Greek at the University of Cambridge for three years before settling in Strassburg.

Enzinas' published works, which often appeared under the pseudonyms of Francisco de Chesne and Dryander, included a history of religion in Spain and translations of Livy and Plutarch. His memoirs, written in Latin and translated into French, were left unpublished until the mid-19th century.