According to his own account, Equiano was kidnapped at age 11 and taken to the West Indies. From there he went to Virginia, where he was purchased by a sea captain, Michael Henry Pascal, with whom he traveled widely. He received some education before he bought his own freedom in 1766. After he settled in England, he became an active abolitionist, agitating and lecturing against the cruelty of British slave owners in Jamaica. He briefly was commissary to Sierra Leone for the Committee for the Relief of the Black Poor; his concerns for the settlers—some 500 to 600 freed slaves—and for their ill treatment before their journey ultimately led to his replacement.

Publication of his autobiography was aided by British abolitionists, including Hannah More (More, Hannah), Josiah Wedgwood (Wedgwood, Josiah), and John Wesley (Wesley, John), who were collecting evidence on the sufferings of slaves. In that book and in his later Miscellaneous Verses… (1789), he idealizes Africa and shows great pride in the African way of life, while attacking those Africans who trafficked in slavery (a perspective further shown by his setting forth not only the injustices and humiliations endured by slaves but also his own experience of kindness, that of his master and a community of English women). As a whole, Equiano's work shows both broad human compassion and realism.

Equiano is often regarded as the originator of the slave narrative because of his firsthand literary testimony against the slave trade. Despite the controversy regarding his birth, The Interesting Narrative remains an essential work both for its picture of 18th-century Africa as a model of social harmony defiled by Western greed and for its eloquent argument against the barbarous slave trade. A critical edition of The Interesting Narrative, edited by Werner Sollors—which includes an extensive introduction, selected variants of the several editions, contextual documents, and early and modern criticism—was published in 2001.