city, seat of Macon county, east-central Alabama, U.S., adjacent to Tuskegee National Forest, about 40 miles (65 km) east of Montgomery. It was founded in 1833, and its name was a variation of Taskigi, a nearby Creek Indian village. Fort Decatur (built 1814), near the city on the Tallapoosa River, was the original burial place of John Sevier (Sevier, John), a noted frontiersman who had been appointed commissioner to determine the boundary of the Creek lands.

The city is best known as the seat of Tuskegee University (1881), originally a school for training African American teachers and now a private, coeducational institution of higher learning. The noted educator Booker T. Washington (Washington, Booker T) was principal of the school from its founding until his death in 1915. The university and a hospital form the basis of the city's economy; there is also some light manufacturing. Chewacla State Park is nearby. The George Washington Carver (Carver, George Washington) Museum, dedicated to the chemist who spent most of his career at Tuskegee, and The Oaks, Washington's home, are located on the university campus. Inc. 1843. Pop. (1990) 12,257; (2000) 11,846.