ʿAkko was a principal base of the Romans when they suppressed the Jewish revolt of AD 66–70. Later conquerors include the Persians (614), the Arabs (638), and the crusaders (1104), who named the city St. Jean d'Acre and made it their last capital. Its capture in 1291 by the Mamlūk sultan al-Ashraf Khalil (reigned 1290–93) marked the end of crusader rule in the Holy Land. From 1516 to 1918 ʿAkko was, except for brief intervals, under the rule of the Ottoman Turks. In 1918 it was taken by British forces and subsequently became a part of Palestine under British mandate (1922).

The city's old fortifications and citadel were strengthened by Ahmad Pasha al-Jazzār (Arabic: “The Butcher”), the Turkish governor (1775–1804), and withstood Napoleon's siege (1799). Though the city had surrendered to the Egyptian viceroy Ibrahīm Pasha in 1832, the citadel itself had never been successfully forced until May 3, 1948, when, as a British prison, it was taken by the Irgun Zvai Leumi, a Jewish guerrilla group. ʿAkko was occupied by regular Israeli troops on May 17, 1948. Though most of the city's Arab inhabitants fled during the Israeli takeover, about 3,000 remained; the city's population in the late 20th century was about three-fourths Jewish.

ʿAkko's ancient port has silted up in modern times and has become secondary to Haifa's across the bay. It is used only by small fishing boats. Industries in modern ʿAkko include a steel-rolling mill and match, tile, and plastic plants. Prominent structures, aside from the citadel, include the Great Mosque, built by Al-Jazzār and named for him; the Municipal Museum, housed in the Pasha's bathhouse; the Crypt of St. John, actually a crusader refectory; and several churches built on crusader foundations. Just north of the city is the tomb of Bahāʾ Ullāh, Iranian founder of the Bahāʾī faith. To the south is a large industrial zone; paint factories are found in the east. The city remains the major trade centre for Arab settlements in western Galilee and is becoming popular with tourists. ʿAkko is the site of the Nautical College of the Israeli navy. The city was designated a UNESCO World Heritage site in 2001. Pop. (2006 est.) 45,900.