Italian painter, daughter of Orazio Gentileschi (Gentileschi, Orazio), who was a major follower of the revolutionary Baroque painter Caravaggio. She was an important second-generation proponent of Caravaggio's dramatic realism.

Shortly after the trial she married a Florentine, and in 1616 she joined Florence's Academy of Design, the first woman to do so. While in Florence she began to develop her own distinct style. Unlike many other women artists of the 17th century, she specialized in history painting rather than still life and portraiture. In Florence she was associated with the Medici court and painted an Allegory of Inclination (c. 1616) for the series of frescoes honouring the life of Michelangelo in the Casa Buonarotti. Her colours are more brilliant than her father's, and she continued to employ the tenebrism made popular by Caravaggio long after her father had abandoned that style.

Artemisia Gentileschi was in Rome for a time and also in Venice. About 1630 she moved to Naples, and in 1638 she arrived in London, where she worked alongside her father for King Charles I. They collaborated on the ceiling paintings of the Great Hall in the Queen's House in Greenwich. After Orazio's death in 1639, she stayed on in London for at least several more years. According to her biographer Baldinucci (who appended her life to that of her father), she painted many portraits and quickly surpassed her father's fame. Later, probably in 1640 or 1641, she settled in Naples, where she painted several versions of the story of David and Bathsheba, but little is known of the final years of her life.