member of a great Romanian princely family, prominent man of letters, economist, and prime minister of Romania (1866–67, 1870–71).

Ghica was descended from the Walachian prince Grigore III Ghica. He figured prominently in the revolutionary activity of 1848 and was subsequently forced into exile. Named prince of Samos by the Turkish government in 1854, he headed the administration of the island for a time before returning to Romania. In 1866 he joined the secret committee that secured the overthrow of the first prince of united Romania, Alexandru Cuza, and his replacement by Prince Karl of Hohenzollern-Sigmaringen, thereafter Carol I (prince, 1866–81; subsequently king). Twice prime minister in 1866, Ghica, during his second administration, won the agreement of the Sultan to Carol's accession. He served again as prime minister in 1870–71 and was subsequently Romanian minister in London (1880–87). He wrote extensively on economic questions and was an exponent of free trade and industrialization. Among his works, Scrisori către V. Alecsandri (“Letters to V. Alecsandri”) is best known.