large cell characterized by an arc of nuclei (nucleus) toward the outer membrane. The cell is formed by the fusion of epithelioid cells, which are derived from immune cells called macrophages. Once fused, these cells share the same cytoplasm, and their nuclei become arranged in an arc near the outer edge of the cell. Langhans' giant cells typically form at the centre of granulomas (aggregates of macrophages) and are found in the tubercle, or primary focus of infection, in tuberculosis, in lesions of syphilis, leprosy, and sarcoidosis, and in fungal infections.

Large cells that form by fusion in reaction to the presence in the body of foreign substances differ from Langhans' giant cells in that their many nuclei are scattered throughout the cell. In giant-cell tumours (tumour) of bone and tendon the cells have many nuclei crowded together. The megakaryocytes, the normal bone-marrow (bone marrow) cells thought to be the source of the blood platelets (platelet), are also called giant cells.