Pilgrims who in 1620 immigrated to America on the Mayflower and took part in the founding of the Plymouth Colony, (Plymouth) the first permanent English colony in New England.

John Alden was hired as a cooper by the London merchants who financed the expedition to the New World. Priscilla Mullins went to America with her parents and younger brother. The other three members of her family died during the terrible first winter of the Plymouth Colony. Probably in 1623 she and John were married. They lived in Plymouth until about 1631, when they and others founded the settlement of Duxbury (now in Massachusetts). They had 11 children, but virtually nothing else is known of Priscilla's later life. The date of her death is unknown, but it may well have occurred before her husband's in 1687. John Alden became a prominent figure in colonial Massachusetts. From his farm at Duxbury he served in a variety of civic capacities: agent for the colony, surveyor of highways, deputy from Duxbury, member of the local council of war, treasurer, and, most important, assistant to the governor of Massachusetts (1623–41 and 1650–86). During this time he twice served as deputy governor. When he died, he was the last male survivor of the Mayflower Company.

Two popular myths have combined to perpetuate a romantic aura about the memory of the Aldens. One claimed he was the first Pilgrim to set foot on Plymouth Rock. The other, which arose from a legend transmitted orally in the family, was dramatized in Henry Wadsworth Longfellow's poem “The Courtship of Miles Standish” (1858). In that legend, Alden presumably won the hand of Priscilla after first wooing her for his friend Standish (Standish, Myles). Because of the story, Priscilla Alden alone, among the women of the Plymouth Colony, is remembered by name. The tale of the triumph of romantic love is nearly unique in the lore of the Pilgrims and is probably not founded in fact; nonetheless, the story—especially Priscilla's alleged words "Why don't you speak for yourself, John?"—remains a part of American folklore.