American biophysicist and animal behaviourist known for his research in animal navigation, acoustic orientation, and sensory biophysics. He is credited with founding cognitive ethology, a field that studies thought processes in animals.

Griffin received a Ph.D. from Harvard University in 1942. As a Harvard undergraduate, he discovered that bats (bat) produce ultrasonic sounds and avoid objects that reflect these sounds, thus proving that the animals orient themselves by echolocation. He was a research assistant in the Psycho-Acoustic Laboratory, Fatigue Laboratory, and other biological laboratories at Harvard from 1942 until 1945. He taught zoology at Cornell University in Ithaca, New York (1946–53), and at Harvard (1953–65). In 1965 he became a professor at Rockefeller University in New York and a research zoologist for the New York Zoological Society; he retired from Rockefeller University in 1986. In the late 1970s Griffin argued that animals might possess the ability to think and reason. His work sparked much controversy in the science community and gave rise to cognitive ethology.

Griffin wrote Listening in the Dark (1958), Echoes of Bats and Men (1959), Animal Structure and Function (1962), Bird Migration (1964), and The Question of Animal Awareness (1976).