former town, now a southeastern section of El Paso, El Paso county, extreme western Texas, U.S. Ysleta lies near the Rio Grande. The town was annexed by El Paso in 1955, though residents of Ysleta had voted against the merger.

Regarded as the oldest settlement within the present boundaries of Texas, Ysleta was founded in 1681–82 by Spanish padres and Christian Indians who, because of a Pueblo Indian uprising, had fled from their settlements along the upper Rio Grande in the region of La Ysleta (an alternate spelling for the Spanish isleta 【“island”】) in what is now New Mexico. The refugees first sought the protection of the Spanish fort El Paso del Norte (now Juarez, Mexico, across the river) and then moved to the present site to found Ysleta del Sur and build the mission Nuestro Señora del Carmen (1682), the oldest mission in Texas (now largely reconstructed).

The Ysleta section of El Paso is characterized by whitewashed old adobe buildings standing between modern structures. The Tigua (Tiwa) Indians maintain a museum and an arts and crafts centre in Ysleta, where the tribe had a small reservation; many members of this group are direct descendants of the Indians who fled the Pueblo revolt. The tribe was officially recognized by the state of Texas in 1967 and by the U.S. Congress the following year. A small stretch of irrigated land just east of the mission is claimed to be the oldest continuously cultivated plot in the United States; originally plowed in 1681, it was planted with corn (maize) and later grapes and a high grade of Egyptian long-staple cotton.