the chain, or law, of dependent origination, or the chain of causation—a fundamental concept of Buddhism describing the causes of pain and the course of events that lead a being through rebirth, old age, and death.

Existence is seen as an interrelated flux of phenomenal events, material and psychical, without any real, permanent, independent existence of their own. These events happen in a series, one interrelating group of events producing another. The series is usually described as a chain of 12 links (Sanskrit nidānas, “causes”), though some texts abridge these to 10, 9, 5, or 3. The first two stages are related to the past (or previous life) and explain the present, the next eight belong to the present, and the last two represent the future as determined by the past and what is happening in the present. The series consists of: (1) ignorance (Sanskrit: avidyā; Pāli: avijjā), specifically ignorance of the Four Noble Truths, of the nature of man, of transmigration, and of nirvana; which leads to (2) faulty thought constructions about reality (saṃskāra/sankhāra). These in turn provide the structure of (3) knowledge (vijñāna/viññāṇa (vijñāna)), the object of which is (4) name and form—i.e., the principle of individual identity (nāma-rūpa) and the sensory perception of an object—which are accomplished through (5) the six domains (ṣaḍāyatana)—i.e., the five senses and their objects—and the mind as the coordinating organ of sense impressions. The presence of objects and senses leads to (6) contact (sparśa/phassa) between the two, which provides (7) sensation ( vedanā). Because this sensation is agreeable, it gives rise to (8) thirst (tṛṣṇā/taṇhā) and in turn to (9) grasping (upādāna), as of sexual partners. This sets in motion (10) the process of becoming (bhava), which fructifies in (11) birth (jāti) of the individual and hence to (12) old age and death (jarā-maraṇa).

The formula is repeated frequently in early Buddhist texts, either in direct order (anuloma) as above, in reverse order (pratiloma), or in negative order (e.g., “What is it that brings about the cessation of death? The cessation of birth”). Gautama Buddha is said to have reflected on the series just prior to his enlightenment, and a right understanding of the causes of pain and the cycle of rebirth leads to emancipation from the chain's bondage.

The formula led to much discussion within the various schools of early Buddhism. Later, it came to be pictured as the outer rim of the wheel of becoming (bhavacakra), frequently reproduced in Tibetan painting.