Czech poet noted for his detached, lyrical reflections on humanist and scientific subjects.

A clinical pathologist and immunologist by profession, Holub received his M.D. from the Charles University School of Medicine (1953) and his Ph.D. from the Czechoslovak (now Czech) Academy of Sciences Institute of Microbiology (1958), both in Prague. His first poetry was published in 1947; by the mid-1950s he was associated with the young writers of the literary magazine Květen, who opposed the bombastic Socialist Realism promoted by Czechoslovakia's communist rulers. His first verse collection was Denní služba (1958; “Day Duty”), and he wrote 10 additional collections by 1971, including Achilles a želva (1960; “Achilles and the Tortoise”), Tak zvané srdce (1963; “The So-Called Heart”), and Ačkoli (1969; Although).

By the late 1960s some of his poetry had been translated into English, including Selected Poems (1967); later collections of his poetry in translation include Notes of a Clay Pigeon (1977), On the Contrary and Other Poems (1984), Poems Before & After (1990), Intensive Care: Selected and New Poems (1996), and The Rampage (1997). He traveled often in English-speaking countries, where he was at least as well known as in his homeland; among his prose writings are Anděl na kolečkách: poloreportáž z USA (1963; “Angel on Wheels: Sketches from the U.S.A.”) and Žit v New Yorku (1969; “To Live in New York”). Despite being a prolific poet, Holub considered science his primary concern, and by 1991 he had written more than 120 scientific papers and monographs. His medical background is evident in much of his poetry, such as the 1980 collection Sagitální řez (Sagittal Section).