private, coeducational institution of higher learning in Worcester, Massachusetts, U.S. It is affiliated with the Jesuit order of the Roman Catholic church. An undergraduate institution, Holy Cross offers a traditional liberal arts curriculum as well as cooperative degree programs with other universities in engineering and business. Campus facilities include an art gallery, a greenhouse, and an aquatic research laboratory. Total enrollment is approximately 2,700.

Holy Cross, the oldest Catholic college in New England, was founded in 1843. Benedict Joseph Fenwick, the second bishop of Boston, was instrumental in the creation of the college. Women were first admitted to Holy Cross in 1972. Notable alumni include basketball player Bob Cousy (Cousy, Bob) and surgeon Joseph E. Murray (Murray, Joseph E.), who was a cowinner of the Nobel Prize for Physiology or Medicine in 1990.