(May 28, 1830), first major legislative departure from the U.S. policy of officially respecting the legal and political rights of the American Indians. The act authorized the president to grant Indian tribes unsettled western prairie land in exchange for their desirable territories within state borders (especially in the Southeast), from which the tribes would be removed. The rapid settlement of land east of the Mississippi River made it clear by the mid-1820s that the white man would not tolerate the presence of even peaceful Indians there. Pres. Andrew Jackson (1829–37) vigorously promoted this new policy, which became incorporated in the Indian Removal Act of 1830. Although the bill provided only for the negotiation with tribes east of the Mississippi on the basis of payment for their lands, trouble arose when the United States resorted to force to gain the Indians' compliance with its demand that they accept the land exchange and move west.

A number of northern tribes were peacefully resettled in western lands considered undesirable for the white man. The problem lay in the Southeast, where members of what were known as the Five Civilized Tribes ( Chickasaw, Choctaw, Seminole, Cherokee, and Creek) refused to trade their cultivated farms for the promise of strange land in the Indian Territory with a so-called permanent title to that land. Many of these Indians had homes, representative government, children in missionary schools, and trades other than farming. Some 100,000 tribesmen were forced to march westward under U.S. military coercion in the 1830s; up to 25 percent of the Indians, many in manacles, perished en route. The trek of the Cherokee in 1838–39 became known as the infamous “ Trail of Tears” (see Cherokee). Even more reluctant to leave their native lands were the Florida Indians, who fought resettlement for seven years (1835–42) in the second of the Seminole Wars.

The frontier began to be pushed aggressively westward in the years that followed, upsetting the “guaranteed” titles of the displaced tribes and further reducing their relocated holdings.