Known or suspected chemical carcinogens

target organ agents industries tumour type

lung tobacco smoke, arsenic, asbestos, crystalline silica, benzo(a)pyrene, beryllium, bis-chloromethyl ether, 1,3-butadiene, chromium

VI compounds, coal tar and pitch, nickel compounds, soots, mustard gas aluminum production,

coal gasification, coke production, hematite mining, painting squamous cell, large cell, and small cell cancer, adenocarcinoma

pleura asbestos … mesothelioma

oral cavity tobacco smoke, alcoholic beverages, nickel

compounds boot and shoe production, furniture manufacture, isopropyl alcohol production squamous cell cancer

esophagus tobacco smoke, alcoholic beverages … squamous cell cancer

gastric smoked, salted, and

pickled foods rubber adenocarcinoma

colon heterocyclic amines,

asbestos pattern making adenocarcinoma

liver aflatoxin, vinyl chloride, tobacco smoke, alcoholic beverages … hepatocellular carcinoma, hemangiosarcoma

kidney tobacco smoke … renal cell cancer

bladder tobacco smoke, 4-aminobiphenyl,

benzidine, 2-naphthylamine magenta manufacture, auramine manufacture transitional cell cancer

prostate cadmium … adenocarcinoma

skin arsenic, benzo(a)pyrene,

coal tar and pitch, mineral

oils, soots coal gasification, coke production squamous cell cancer, basal cell cancer

bone marrow benzene, tobacco smoke, ethylene oxide,

antineoplastic drugs rubber leukemia

Source: Taken from Vincent T. DeVita, Jr., Samuel Hellman, and Steven A. Rosenberg (eds.), Cancer: Principles & Practice of Oncology (1997).