Guaiacum officinale occurs from the southern United States to northern South America. It grows about 9 m (30 feet) tall and reaches a diameter of about 25 cm (10 inches). The evergreen leaves are opposite, divided into leaflets (arranged along an axis), and leathery in texture. The flowers are bright blue when first open but gradually fade to white. The yellow, heart-shaped fruit is about 2 cm (0.8 inch) long.

The tree is the source of a very hard, heavy wood that is brownish green in colour. It is used to make pulleys, shafts, axles, and bowling balls. The wood is relatively waterproof because of its high fat content. The resin, called guaiacum, is obtained from the wood by distillation; it is used to treat respiratory disorders.