neighbourhood in the borough of Tower Hamlets in the East End of London.

The name of the district derives from the limekilns that were on the riverbank at least as early as the 14th century. (The sometimes pejorative term Limey for Englishman, erroneously thought to derive from the sailors of Limehouse, derives from the unrelated term lime-juicer, from the use of lime juice by sailors to prevent scurvy.) In the 18th and 19th centuries Limehouse formed a vital component of the Port of London's international trade. The lure of employment in the London Docklands brought many immigrants to the area, notably Chinese and other Asian groups. Limehouse, along with other riverside neighbourhoods, was extensively bombed during World War II.

One of the few historic structures to survive the war, the parish church of St. Anne's (1712–24) was designed by Nicholas Hawksmoor (Hawksmoor, Nicholas). Many seamen's hostels and public houses still enhance the character of the district, although the nearby docks closed in the 20th century.