Christian theologian-martyr who originated a theological tradition at Antioch that was noted for biblical linguistic scholarship and for a rationalist approach to Christian doctrine.

In his principal work, Lucian analyzed the Greek text of both the Old and New Testaments, creating a tradition of manuscripts known as the Lucianic Byzantine, or Syrian, text. Until the development of 19th-century biblical criticism, its clarity made it the common text. By comparative study of the Greek and Hebrew grammatical styles in their Semitic background, Lucian proposed to limit the symbolical interpretation characteristic of the Alexandrian (Egyptian) allegorical tradition by emphasizing the primacy of the literal sense, whether expressed directly or metaphorically.

Such analytical methods influenced Antiochene theological formulations by Lucian's students and colleagues relative to doctrines on Christ and the divine Trinity. Later critics, including Alexander of Alexandria, during the Council of Nicaea in 325, associated Lucian's school with the condemned theological revisions of Arius and his attack on the absolute divinity of Christ. Lucian, in 269, had also been implicated with the denounced teachings—known as Monarchianism—of the Antiochene bishop Paul of Samosata. Church authorities subsequently accepted Lucian's conciliatory statement of belief in 289 and, posthumously, in 341 at a church council in Antioch. Lucian's influence permanently oriented Christian theology toward a historical realist approach in its debate with classical non-Christian thought.

Lucian's martyrdom by torture and starvation for refusing to eat meat ritually offered to the Roman gods during the early-4th-century persecution of the Roman emperor Maximinus elicited praise from his antagonists.