any of six plant species belonging to the genus Mandragora (family Solanaceae) that are native to the Mediterranean region and the Himalayas. The best-known species, M. officinarum, has a short stem bearing a tuft of ovate flowers, with a thick, fleshy root that is often forked. The flowers are solitary, with a purple bell-shaped corolla, and the fruit is a fleshy orange-coloured berry.

The mandrake has long been known for its poisonous properties. In ancient times it was used as a narcotic and an aphrodisiac, and it was also believed to have certain magical powers. Its forked root, seemingly resembling the human form, was thought to be in the power of dark earth spirits. It was believed that the mandrake could be safely uprooted only in the moonlight, after appropriate prayer and ritual, by a black dog attached to the plant by a cord. Human hands were not to come in contact with the plant. In medieval times it was thought that as the mandrake was pulled from the ground it uttered a shriek that killed or drove mad those who did not block their ears against it. After the plant had been freed from the earth, it could be used for beneficent purposes, such as healing, inducing love, facilitating pregnancy, and providing soothing sleep.

In North America, the name mandrake is often used for the mayapple of the family Berberidaceae.