(from Greek anatithenai: “to set up,” or “to dedicate”), in the Old Testament, a creature or object set apart for sacrificial offering. Its return to profane use was strictly banned, and such objects, destined for destruction, thus became effectively accursed as well as consecrated. Old Testament descriptions of religious wars call both the enemy and their besieged city anathema inasmuch as they were destined for destruction.

In New Testament usage a different meaning developed. St. Paul used the word anathema to signify a curse and the forced expulsion of one from the community of Christians. In AD 431 St. Cyril of Alexandria pronounced his 12 anathemas against the heretic Nestorius. In the 6th century anathema came to mean the severest form of excommunication that formally separated a heretic completely from the Christian church and condemned his doctrines; minor excommunications, while prohibiting free reception of the sacraments, obliged (and permitted) the sinner to rectify his sinful state through the sacrament of penance.