The eggs are laid on a surface of water and hatch into aquatic larvae, or wrigglers, which swim with a jerking, wriggling movement. In most species, larvae feed on algae and organic debris, although a few are predatory and may even feed on other mosquitoes. Unlike most insects, mosquitoes in the pupal stage, called tumblers, are active and free-swimming. The pupae breathe by means of tubes on the thorax. The adults mate soon after emerging from their pupal cases. The duration of the life cycle varies greatly depending on the species.

Mosquitoes are apparently attracted to host animals by moisture, lactic acid, carbon dioxide, body heat, and movement. The mosquito's hum results from the high frequency of its wingbeats, and the female's wingbeat frequency may serve as a means of sex recognition.

Measures used to control mosquitoes include the elimination of breeding sites, the application of surface films of oil to clog the breathing tubes of wrigglers, and the use of larvicides. Insecticides at times are used to destroy adult mosquitoes indoors.

There are three important mosquito genera. Anopheles, the only known carrier of malaria, also transmits filariasis and encephalitis. Anopheles mosquitoes are easily recognized in their resting position, in which the proboscis, head, and body are held on a straight line to each other but at an angle to the surface. The spotted colouring on the wings results from coloured scales. Egg laying usually occurs in water containing heavy vegetation. The female deposits her eggs singly on the water surface. Anopheles larvae lie parallel to the water surface and breathe through posterior spiracular plates on the abdomen instead of through a tube, as do most other mosquito larvae. The life cycle is from 18 days to several weeks.

The genus Culex is a carrier of viral encephalitis and, in tropical and subtropical climates, of filariasis. It holds its body parallel to the resting surface and its proboscis is bent downward relative to the surface. The wings, with scales on the veins and the margin, are uniform in colour. The tip of the female's abdomen is blunt and has retracted cerci (sensory appendages). Egg laying may occur on almost any body of fresh water, including standing polluted water. The eggs, which float on the water, are joined in masses of 100 or more. The long and slender Culex larvae have breathing tubes that contain hair tufts. They hang head downward at an angle of 45° from the water surface. The life cycle, usually 10 to 14 days, may be longer in cold weather. C. pipiens pipiens is the most abundant house mosquito in northern regions, while C. pipiens quinquefasciatus is abundant in southern regions.

The genus Aedes carries yellow fever, dengue, and encephalitis. Like Culex, it holds its body parallel to the surface with the proboscis bent down. The wings are uniformly coloured. Aedes may be distinguished from Culex by its silver thorax with white markings and posterior spiracular bristles. The tip of the female's abdomen is pointed and has protruding cerci. Aedes usually lays eggs in floodwater, rain pools, or salt marshes. The eggs are capable of withstanding long periods of dryness. The short, stout larvae have a breathing tube containing a pair of tufts, and the larvae hang head down at a 45° angle from the water surface. The life cycle may be as short as 10 days or, in cool weather, as long as several months. A. aegypti, the important carrier of yellow fever, has white bands on its legs and spots on its abdomen and thorax. This domestic species breeds in almost any kind of container, from flower pots to discarded car-tire casings. A. sollicitans, A. taeniorhynchus, and A. dorsalis are important salt-marsh mosquitoes. They are prolific breeders, strong fliers, and irritants to animals, including humans.