town, Saône-et-Loire département, Burgundy région, east-central France, north of Lyon. On the right bank of the Saône River, it is skirted by France's main highway, the Autoroute du Sud, and by the Mâcon-Geneva highway, the principal route from the Loire region to Geneva. It is also a railway crossroads and has a river port on the Saône, accessible by large-capacity barges (although traffic is minimal). The Saône is traversed by the restored 14th-century St. Laurent Bridge. Called Matisco by the Romans, Mâcon was an episcopal see from 536 to 1790. The former Cathedral of Saint-Vincent was largely demolished in 1799. Old buildings include the house, now the museum, in which the 19th-century poet and politician Alphonse de Lamartine was born.