Within the olfactory bulb are discrete spheres of nerve tissue called glomeruli. They are formed from the branching ends of axons of receptor cells and from the outer (dendritic) branches of interneurons, known in vertebrates as mitral cells, that pass information to other parts of the brain. Tufted cells, which are similar to but smaller than mitral cells, and periglomerular cells, another type of interneuron cell, also contribute to the formation of glomeruli. The axons of all the receptor cells that exhibit a response to a specific chemical or range of chemicals with similar structures converge on a single glomerulus, where they connect via synapses with the interneurons. In this way, information from large numbers of receptor cells with similar properties is brought together. Thus, even if only a few receptors are stimulated because of very low concentrations of the stimulating chemical, the effects of signals from these cells are maximized. In mice (mouse) there are about 1,800 glomeruli on each side of the brain, in rabbits (rabbit) there are about 2,000, and in dogs (dog) there are as many as 5,000. Since there are millions of olfactory receptor cells, the degree of convergence of axons, and therefore of information about a particular odour, is enormous. For example, in a rabbit, axons from about 25,000 receptor cells converge on each glomerulus.

Terrestrial vertebrates appear to have fewer glomeruli than fish. zebra fish, commonly used in laboratory studies, have about 80 glomeruli in each olfactory bulb, and the mitral cells, which synapse (connect) with the axons of receptor cells in the glomeruli, have axons extending to several glomeruli, whereas in mammals (mammal) the main connection of each mitral cell is with one glomerulus.