the favourite consort of the Ottoman sultan Murad III (reigned 1574–95) and the mother of his son Mehmed III (reigned 1595–1603); she exercised a strong influence on Ottoman affairs during the reigns of both sultans.

Safiye, whose name means “pure one,” is said to have been a native of Rezi, a mountain town in Albania. Until the death in 1583 of Nur Banu, the valide sultan (mother of the sultan on the throne), Safiye's influence was limited. Thereafter, as haseki sultan (mother of the heir to the throne), and after 1595 as valide sultan, she wielded great influence at the Ottoman court. Among those who enjoyed her favour was the thrice grand vizier (chief minister) İbrahim Paşa. During the years of her greatest influence, she is said to have been partial to the interests of Venice. She was sent into retirement after the death of Mehmed III.

A mosque at Cairo, the Malikah Ṣafīyah, bears her name. Another mosque, in Istanbul, the Yeni Valide Cami, was begun on her orders and completed under Sultan Mehmed IV (reigned 1648–87).