American actor who was perhaps best known for his comedic roles, most notably the “defective detective” Adrian Monk in the USA network television series Monk.

Shalhoub was the son of Lebanese immigrants, and he was drawn to acting at an early age, making his debut in a high-school production of The King and I. Shalhoub attended the University of Southern Maine (B.A., 1977) and Yale University's School of Drama (M.A., 1980). Early in his career, he focused on stage work, performing with the American Repertory Theatre in Cambridge, Mass., and in several theatrical productions at the New York Shakespeare Festival. He soon found success on Broadway in The Heidi Chronicles (1989) and earned a Tony Award nomination for his performance in Herb Gardner's Conversations with My Father (1992).

Shalhoub ventured into television in 1986 playing a terrorist in the series The Equalizer, and he appeared in 1988 in his first television movie, Alone in the Neon Jungle. He quickly moved on to more-substantial roles, portraying Enrico Fermi in the Emmy Award-winning Day One (1989) and the romantic taxi driver Antonio Scarpacci in the series Wings (1991–97). Shalhoub's versatility allowed him to transfer easily to the big screen, where his most memorable performances included a pawnbroker with a surprisingly regenerative head in the Men in Black films (1997, 2002), a Muslim antiterrorist FBI agent in The Siege (1998), and the comic villain Alexander Minion in the Spy Kids series (2001–03). Shalhoub demonstrated his command of foreign dialects and talent for comedy as a non-English-speaking cab driver in Quick Change (1990), opposite Bill Murray, and he costarred as the moody chef Primo in Big Night (1996). In the animated film Cars (2006), he provided the voice for the vehicle Luigi.

It was Shalhoub's ability to absorb himself totally in character roles that proved key to the success of his portrayal of the obsessive-compulsive detective Adrian Monk. The series premiered in 2002 and earned Shalhoub numerous honours, including multiple Emmy Awards (Emmy Award) (2003, 2005, 2006) and Screen Actors Guild Awards (2004, 2005). In 2003 he received a Golden Globe Award.