Coccidioidomycosis may be benign and self-limiting, or it may be progressive, spreading throughout the body. In about 50 percent of the cases of benign coccidioidomycosis there are no symptoms. When symptoms occur, they resemble symptoms of influenza or pneumonia: fever, chills, headache, severe pain in the joints, chest pain, and coughing. In a few instances after recovery there are solid lesions or cavities in the lungs. Disseminated coccidioidomycosis, or coccidioidal granuloma, is a progressive form of infection that can result in skin ulcers, many nodules or cavities in the lungs, widespread involvement of lymph nodes, lesions of the bones, and osteomyelitis (infection of the bone). meningitis is usually the immediate cause of death.

Diagnosis of coccidioidomycosis is made by serologic tests or by culture of the organism. Most cases do not require treatment, but patients with widespread disease can be treated with amphotericin B. See also cryptococcosis.