vizier, sage, architect, astrologer, and chief minister to Djoser (reigned 2630–2611 BCE), the second king of Egypt's third dynasty, who was later worshipped as the god of medicine in Egypt and in Greece, where he was identified with the Greek god of medicine, Asclepius. He is considered to have been the architect of the step pyramid built at the necropolis of Ṣaqqārah in the city of Memphis. The oldest extant monument of hewn stone known to the world, the pyramid consists of six steps and attains a height of 200 feet (61 metres).

Not until the Persian conquest of Egypt in 525 BCE was Imhotep elevated to the position of a full deity, replacing Nefertem in the great triad of Memphis, shared with his mythological parents Ptah, the creator of the universe, and Sekhmet, the goddess of war and pestilence. Imhotep's cult reached its zenith during Greco-Roman times, when his temples in Memphis and on the island of Philae (Arabic: Jazīrat Fīlah) in the Nile River were often crowded with sufferers who prayed and slept there with the conviction that the god would reveal remedies to them in their dreams. The only Egyptian mortal besides the 18th-dynasty sage and minister Amenhotep (Amenhotep, son of Hapu) to attain the honour of total deification, Imhotep is still held in esteem by physicians who, like the eminent 19th-century British practitioner Sir William Osler (Osler, Sir William, Baronet), consider him “the first figure of a physician to stand out clearly from the mists of antiquity.”