The Indus civilization apparently evolved from the villages of neighbours or predecessors, using the Mesopotamian model of irrigated agriculture with sufficient skill to reap the advantages of the spacious and fertile Indus River valley while controlling the formidable annual flood that simultaneously fertilizes and destroys. Having obtained a secure foothold on the plain and mastered its more immediate problems, the new civilization, doubtless with a well-nourished and increasing population, would find expansion along the flanks of the great waterways an inevitable sequel. The civilization subsisted primarily by farming, supplemented by an appreciable but often elusive commerce. Wheat and six-row barley were grown; field peas, mustard, sesame, and a few date stones have also been found, as well as some of the earliest known traces of cotton. Domesticated animals included dogs and cats, humped and shorthorn cattle, domestic fowl, and possibly pigs, camels, and buffalo. The elephant probably was also domesticated, and its ivory tusks were freely used. Minerals, unavailable from the alluvial plain, were sometimes brought in from far afield. Gold was imported from southern India or Afghanistan, silver and copper from Afghanistan or northwestern India (Rajasthan), lapis lazuli from Afghanistan, turquoise from Iran (Persia), and a jadelike fuchsite from southern India.

How and when the civilization came to an end remains uncertain. In fact, no uniform ending need be postulated for a culture so widely distributed. But the end of Mohenjo-daro is known and was dramatic and sudden. Mohenjo-daro was attacked toward the middle of the 2nd millennium BCE by raiders who swept over the city and then passed on, leaving the dead lying where they fell. Who the attackers were is matter for conjecture. The episode would appear to be consistent in time and place with the earlier Aryan onslaught upon the Indus region as reflected in the older books of the Rigveda, in which the newcomers are represented as attacking the “walled cities” or “citadels” of the aboriginal peoples and the Aryan war-god Indra as rending forts “as age consumes a garment.” However, one thing is clear: the city was already in an advanced stage of economic and social decline before it received the coup de grâce. Deep floods had more than once submerged large tracts of it. Houses had become increasingly shoddy in construction and showed signs of overcrowding. The final blow seems to have been sudden, but the city was already dying. As the evidence stands, the civilization was succeeded in the Indus valley by poverty-stricken cultures, deriving a little from a sub-Indus heritage but also drawing elements from the direction of Iran and the Caucasus—from the general direction, in fact, of the Aryan invasions. For many centuries urban civilization was dead in the northwest of the Indian subcontinent.

In the south, however, in Kathiawar and beyond, the situation appears to have been very different. Here it would seem that there was a real cultural continuity between the late Indus phase and the Copper Age cultures that characterized central and western India between 1700 and the 1st millennium BCE. These cultures form a material bridge between the end of the Indus civilization proper and the developed Iron Age civilization that arose in India about 1000 BCE. The ruins of Mohenjo-daro were designated a UNESCO World Heritage site in 1980.