city of central Greece in the Sperkhiós River valley at the foot of the Óthris Mountains, near the Gulf of Euboea. It is the capital of the Fthiótis nomós (department) and the seat of a bishop of the Greek Orthodox church. Lamía commands the strategic Foúrka Pass leading northwestward into Thessaly (Thessalía).

The original Lamía was founded in the 5th century BC as the centre of the tribes of Malis, a semi-indigenous Dorian people who contributed to the construction of a temple at Delphi. Upon the decline of Sparta and Thebes in the second half of the 4th century BC, Lamía passed under the influence of Macedonia and Thessaly. It was besieged by the Second Athenian Confederation during the Lamian War (323–322) in that confederation's futile attempt to throw off Macedonian hegemony. In the 3rd century Lamía came under the influence of the expanded Aetolian League, which invited the Seleucid king Antiochus III to Lamía (192); this imprudent gesture provoked the Romans, who destroyed Lamía. In the Middle Ages Lamía was renamed Gipton and turned into a stronghold of the Frankish dukes of Athens. The succeeding Catalans named it El Cito, and to the Turks it was known as Zituni or Zeytun. The acropolis dominating the modern city has ruins that range from classical wall foundations to Roman, Catalan, and Turkish battlements.

Lamía's industries include soap, cotton textiles, and tobacco processing, and there is trade in wheat, olives, and citrus from the Sperkhiós valley. It is linked to Vólos and Larissa by the Athens-Thessaloníki (Salonika) superhighway, and a spur from the Athens-Thessaloníki railway runs to Lamía and its port, Stilís. The area has both iron and manganese deposits. Pop. (1981) 41,846.