private, coeducational institution of higher learning in Philadelphia, Pennsylvania, U.S. It is operated by the Christian Brothers (Christian Brother), a teaching order of the Roman Catholic church (Roman Catholicism). It comprises schools of Arts and Sciences, Business Administration, and Nursing, offering a range of bachelor's and master's degree programs in nursing, education, business, computer sciences, central and eastern European studies, and other areas. Students can spend a year of study in Switzerland or Spain. The university has a cooperative relationship with nearby Chestnut Hill College, a Catholic college for women. Total enrollment is approximately 6,300.

The university was founded in 1863 and named for St. Jean-Baptiste de La Salle (La Salle, Saint Jean-Baptiste de), founder of the Christian Brothers. The university occupied several locations throughout Philadelphia before settling on a portion of Belfield Farm, the former home of the painter Charles Willson Peale (Peale, Charles Willson). Women were first admitted as full-time students in 1970.