city, seat (1879) of Brevard county, east-central Florida, U.S., about 35 miles (55 km) east of Orlando. The city, on the Intracoastal Waterway, is situated on the west bank of the Indian River (a lagoon separated from the Atlantic Ocean by barrier islands) and is linked (via a causeway across the river) to the John F. Kennedy Space Center on northern Merritt Island.

In 1513 Spanish explorer Juan Ponce de León (Ponce de León, Juan) visited nearby Cape Canaveral (Canaveral, Cape). Titusville was founded in 1867 near a post office known as Sand Point by Colonel Henry T. Titus, for whom it was renamed in 1873. When incorporated in 1887, it was a port served by a mule-drawn railway that carried freight as far as Sanford, about 30 miles (50 km) inland. In the late 1880s the Jacksonville, Tampa, and Key West Railroad was extended to Titusville, which then developed as a citrus shipping point and commercial fishing port. It consolidated with Indian River City and Whispering Hills in 1963. The advent of space-exploration activities at Cape Canaveral greatly stimulated Titusville's growth in the 1950s and '60s.

The city's economy is dominated by tourism and the nearby aerospace research and industrial complex. The Kennedy Space Center Visitor Complex includes films and exhibits on space exploration as well as a replica space shuttle. Also in Titusville are the U.S. Astronaut Hall of Fame and the Valiant Air Command Warbird Museum, which contains military aircraft memorabilia. Canaveral National Seashore and Merritt Island National Wildlife Refuge (the latter containing the space complex) are just to the east, and St. Johns National Wildlife Refuge is about 5 miles (8 km) southwest. Pop. (1990) city, 39,394; Melbourne–Titusville–Palm Bay MSA, 398,978; (2000) city, 40,670; Melbourne–Titusville–Palm Bay MSA, 476,230.

Titusville's last refinery closed in 1950; lumber, steel products, aluminum castings, and plastic products are now the city's major manufactures. A regional campus (1963) of the University of Pittsburgh (Pittsburgh, University of) is in Titusville. A replica of the original well house and derrick are at the Drake Well Museum. Inc. borough, 1847; city, 1866. Pop. (1990) 6,434; (2000) 6,146.