mother of King Francis I of France, who as regent twice during his reign played a major role in the government of France.

The daughter of Philip II the Landless, duke of Savoy, and Marguerite de Bourbon, Louise married Charles de Valois-Orléans, comte d'Angoulême; they had two children, Margaret, future queen of Navarre and patron of Humanists and Reformers, and Francis, who became heir presumptive to the French crown on the accession of Louis XII in 1498.

In 1515 Francis ascended the throne and Louise, devoted to her son, took an active part in government. Created duchesse d'Angoulême, she was appointed regent when Francis undertook his first expedition to Italy (1515–16). When her niece Suzanne de Bourbon died in 1521 and left her estate to her husband Charles, the constable duke de Bourbon, Louise claimed the estate for herself, doing much to push Charles to treason (1523).

Regent again in 1525–26, during the king's second Italian expedition, Louise was able to detach Henry VIII of England from his alliance with the Holy Roman emperor Charles V. She was also active in negotiations to free her son from captivity in Spain, and, with Margaret of Austria, she negotiated the Treaty of Cambrai (Cambrai, Treaty of), or “Ladies' Peace,” in 1529 between Francis and Charles V.