city, seat of McCracken county, southwestern Kentucky, U.S., at the confluence of the Ohio (Ohio River) (there bridged to Brookport, Illinois) and Tennessee (Tennessee River) rivers. The site, known as Pekin, was part of a grant to soldier and frontiersman George Rogers Clark (Clark, George Rogers). At his death his brother William (Clark, William), who was coleader of the Lewis and Clark Expedition, received the land, laid out the town in 1827, and named it for Paduke, a Chickasaw Indian chief who lived in the vicinity. During the American Civil War, because of its strategic river facilities, the city was occupied by Union forces under General Ulysses S. Grant (Grant, Ulysses S.) and was raided by General Nathan B. Forrest (Forrest, Nathan Bedford), a Confederate cavalry leader. Severe floods in 1884, 1913, and 1937 prompted construction of a flood wall and dams on the Tennessee, Ohio, and Cumberland (Cumberland River) rivers.

Paducah is now an important market for tobacco, timber, soybeans, livestock, and coal. Located in one of the world's greatest power-generating areas, the city's growth has been greatly stimulated by the Tennessee Valley Authority and Atomic Energy Commission (now U.S. Department of Energy) projects. The Paducah Gaseous Diffusion Plant employs nearly 2,000 people. Recreational facilities are provided by nearby Kentucky Lake and Kentucky Dam Village State Park. Paducah Community College was founded in 1932. The city calls itself “Quilt City U.S.A.” and is home to the Museum of the American Quilter's Society. Native sons include the humorist Irvin S. Cobb (Cobb, Irvin S) (1876–1944) and Alben W. Barkley (Barkley, Alben W), who served as vice president (1949–53) under Harry S. Truman. Inc. city, 1830. Pop. (1990) 27,256; (2000) 26,307.