After his graduation from Fordham University, New York City (1958), DeLillo worked for several years as a copywriter at an advertising agency. DeLillo's first novel, Americana (1971), is the story of a network television executive in search of the “real” America. It was followed by End Zone (1972) and Great Jones Street (1973). Ratner's Star (1976) attracted critical attention with its baroque comic sense and verbal facility.

Beginning with Players (1977), DeLillo's vision turned darker, and his characters became more willful in their destructiveness and ignorance. Critics found little to like in the novel's protagonists but much to admire in DeLillo's elliptical prose. The thrillers Running Dog (1978) and The Names (1982) followed. White Noise (1985), which won the American Book Award for fiction, tells of a professor of Hitler studies who is exposed to an “airborne toxic event”; he discovers that his wife is taking an experimental substance said to combat the fear of death, and he vows to obtain the drug for himself at any cost. In Libra (1988), DeLillo presented a fictional portrayal of Lee Harvey Oswald (Oswald, Lee Harvey), the assassin of President John F. Kennedy (Kennedy, John F.). Mao II (1991) opens with a mass wedding officiated by cult leader Sun Myung Moon (Moon, Sun Myung). It tells the story of a reclusive writer who becomes enmeshed in a world of political violence.

DeLillo's later works of fiction include Underworld (1997), which provides a commentary on American history in the second half of the 20th century by tracing the journeys of a baseball, as well as Cosmopolis (2003), set largely in a billionaire's limousine as it moves across Manhattan, and Falling Man (2007), which tells the story of a survivor of the September 11 attacks in 2001.